Salvianolic Acid B, IC-01289180
Product Introduction
Salvianolic acid B is a water-soluble polyphenolic compound and the most abundant bioactive constituent of Salvia miltiorrhiza (Danshen), a traditional Chinese medicinal herb widely used in cardiovascular therapy. Salvianolic acid B is a potent antioxidant and free radical scavenger, exhibiting protective effects against oxidative stress-induced cellular damage. Its pharmacological activities include anti-inflammatory, anti-fibrotic, anti-apoptotic, and cardioprotective effects. Salvianolic acid B has been shown to inhibit platelet aggregation, improve microcirculation, protect endothelial cells, and attenuate myocardial ischemia-reperfusion injury. Additionally, it exhibits hepatoprotective, neuroprotective, and anti-tumor activities, and modulates signaling pathways including Nrf2/ARE, NF-κB, and TGF-β/Smad. Salvianolic acid B is widely used in pharmacological, cardiovascular, and natural product research.
Product Features
1. Potent Antioxidant: Effective free radical scavenger and Nrf2/ARE pathway activator.
2. Cardiovascular Protection: Inhibits platelet aggregation, protects endothelial cells, and attenuates ischemia-reperfusion injury.
3. Anti-Fibrotic and Anti-Inflammatory: Modulates NF-κB and TGF-β/Smad signaling pathways.
4. Broad Research Utility: Applied in cardiovascular, hepatic, neurological, and oncological research.
5. High Purity: Supplied at 98% purity for reproducible pharmacological studies.
Specifications
Size: 1 mg / 5 mg / 10 mg / 25 mg
CAS Number: 121521-90-2
Purity: 98%
Molecular Weight: 718.62
Molecular Formula: C36H30O16
Solubility: Water: ≥10 mg/mL; DMSO: ≥20 mg/mL; Ethanol: ≥10 mg/mL
Storage and Stability
Storage Conditions: Store at 2-8°C, protected from light and moisture, under inert atmosphere.
Shelf Life: The product is stable for 24 months from the date of manufacture when stored as directed.
Protocol (For Reference Only)
Important: Salvianolic acid B is light-sensitive and hygroscopic. Protect from light and moisture during handling and storage.
1. Stock Solution Preparation: Dissolve Salvianolic acid B in DMSO, water, or ethanol to prepare a concentrated stock solution (e.g., 10-50 mM). Aliquot into single-use vials and store at -20°C protected from light.
2. In Vitro Working Solution Preparation: Dilute stock solution into culture medium to achieve working concentrations typically ranging from 5-100 µM. Limit final DMSO concentration to ≤0.1%.
3. Antioxidant and Cytoprotection Assays: Pretreat cells with Salvianolic acid B at 5-50 µM for 1-24 hours before exposure to oxidative stressors (e.g., H₂O₂, tert-butyl hydroperoxide). Assess cell viability, ROS levels, and antioxidant enzyme activity.
4. Anti-Fibrotic Studies: Treat fibroblasts or hepatic stellate cells with Salvianolic acid B at 10-50 µM and assess TGF-β-induced collagen synthesis, α-SMA expression, and fibrotic gene expression.
5. In Vivo Studies: Salvianolic acid B has been administered in rodent models via oral or intraperitoneal routes at doses of 10-100 mg/kg. Optimize dosing and formulation based on specific experimental requirements.
Precautions
1. Protect from light and moisture during handling and storage.
2. Use appropriate vehicle controls in all experiments; DMSO concentration in culture medium should not exceed 0.1%.
3. Salvianolic acid B exhibits pleiotropic pharmacological effects; interpret results with consideration of multiple signaling pathways.
4. For research use only. Not for use in diagnostic or therapeutic procedures.
FAQ (Simplified)
Q1: What are the main pharmacological activities of Salvianolic acid B?
A1: Salvianolic acid B exhibits antioxidant, anti-inflammatory, anti-fibrotic, cardioprotective, hepatoprotective, and neuroprotective activities, primarily mediated through Nrf2/ARE, NF-κB, and TGF-β/Smad pathways.
Q2: What is the recommended concentration for in vitro studies?
A2: Typical in vitro working concentrations range from 5-100 µM. Optimize for each cell type and endpoint.
Q3: How should I store Salvianolic acid B?
A3: Store at 2-8°C protected from light and moisture under inert atmosphere. Reconstituted stock solutions should be aliquoted and stored at -20°C protected from light.
Disclaimer
1. For Research Use Only. Not for use in diagnostic or therapeutic procedures.
2. Due to the variable nature of biological research, optimization of conditions is recommended for specific experimental systems.
3. This warranty is limited to the replacement of the product. The manufacturer assumes no liability for incidental or consequential damages.
4. Wear appropriate protective clothing and gloves when handling this product.
Ordering Information
Catalog Number: IC-01289180
Product Name: Salvianolic Acid B
Size: 1 mg / 5 mg / 10 mg / 25 mg
Suggested Retail Price:
1 mg: CNY ¥430.00 / USD $43.00 / EUR �51.60 / JPY ¥7740.00
5 mg: CNY ¥945.00 / USD $94.50 / EUR �113.40 / JPY ¥17010.00
10 mg: CNY ¥1485.00 / USD $148.50 / EUR �178.20 / JPY ¥26730.00
25 mg: CNY ¥3240.00 / USD $324.00 / EUR �388.80 / JPY ¥58320.00
Note: The specific price is subject to the transaction price in the offline contract. This document is provided for technical reference only and does not constitute any form of sales advertisement or invitation to offer. For product details and purchase inquiries, please contact local sales representatives.
