Schizandrin B,61281-37-6

Cat.No.:IC-0906731

Product Information

Biological Activity

Schisandrin B (Sch B), the most abundant dibenzocyclooctadiene lignin, is isolated from the fruit of Schisandra chinensis.In vitro: Schisandrin B has early been found to inhibit in vitro lipid peroxidation by NADPH/ ascorbate and cysteine/ferric systems in isolated rat liver microsomes. In addition, using electron spin resonance measurement, Sch B was shown to scavenge both in vitro hydroxyl and superoxide radicals. In contrast to that ¦Á-tocopherol produced prooxidant and antioxidant effect on Fe3+-induced lipid peroxidation, Sch B could only inhibit the peroxidation reaction [1].In vivo: Five days after a single injection of doxorubicin (Dox) administration (20 mg/kg IP), left ventricular (LV) performance in mice was depressed significantly and was improved by Sch B treatment. Sch B could prevent the Dox-induced lipid peroxidation increase, nitrotyrosine formation, as well as metalloproteinase activation in the heart. Additionally, the increased expression of phosphop38 MAPK and phospho-MAPK activated mitogen kinase 2 levels by Dox were found to be suppressed by Sch B treatment significantly. Moreover, Sch B also attenuated Dox-induced higher expression of LV proinflammatory cytokines, myocardial apoptosis, cardiomyocyte DNA damage, caspase-3 positive cells and phopho-p53 levels in mice [2].

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Order Information

Quantity

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

100mg

€ 119.00

£¤142.80

£¤1,190.00

$23,681.00

500mg

€ 380.00

£¤456.00

£¤3,800.00

$75,620.00

1g

€ 599.00

£¤718.80

£¤5,990.00

$119,201.00

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

400.46

Formula

C23H28O6

CAS Number

61281-37-6

Purity

¡Ý99.00%

Solubility

DMSO:100 mg/mL (249.71 mM£©  

Storage

2-8¡æ for 2years ,-20¡æ for 3 years.

Reference

[1] Mak DH,Ip SP,Li PC,Poon MK,Ko KM.  Effects of Schisandrin B and alpha-tocopherol on lipid peroxidation, in vitro and in vivo. Mol Cell Biochem.1996 Dec 20;165(2):161-5.

[2] Thandavarayan RA,Giridharan VV,Arumugam S,Suzuki K,Ko KM,Krishnamurthy P,Watanabe K,Konishi T.  Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling. PLoS One.2015 Mar 5;10(3):e0119214.

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