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Hemin /Panhematin,16009-13-5 |
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Cat.No.:IC-035319 |
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Product Information |
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Biological Activity |
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Hemin chloride, a substrate of heme oxygenase (HO)-1, induces HO-1 expression on a variety of cells to exert anti-oxidant and anti-inflammatory roles. |
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Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines) |
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Species |
Mouse |
Rat |
Rabbit |
Guinea pig |
Hamster |
Dog |
Weight (kg) |
0.02 |
0.15 |
1.8 |
0.4 |
0.08 |
10 |
Body Surface Area (m2) |
0.007 |
0.025 |
0.15 |
0.05 |
0.02 |
0.5 |
Km factor |
3 |
6 |
12 |
8 |
5 |
20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by (Animal B Km / Animal A Km) |
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Order Information |
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Quantity |
Price($) |
Price(€) |
Availability |
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500mg |
$60.00 |
€72.00 |
In stock |
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5g |
$420.00 |
€504.00 |
In stock |
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50g |
$2,940.00 |
€3,528.00 |
In stock |
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Free Delivery on orders over $350.00. |
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Chemical Information |
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Molecular Weight |
652 |
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Formula |
C34H32ClFeN4O4 |
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CAS Number |
16009-13-5 |
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Purity |
>98.00% |
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Solubility |
2.5 mg/mL in NH4OH,1M NaOH : 6.67 mg/mL. |
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Storage |
4¡ãC, protect from light, stored under nitrogen |
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Reference |
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[1]. Huang H, Dabrazhynetskaya A, et,al.Hemin chloride activation abrogates Mycoplasma hyorhinis replication in chronically infected prostate cancer cells via heme oxygenase-1 induction. FEBS Open Bio. 2021 Oct;11(10):2727-2739. doi: 10.1002/2211-5463.13271. Epub 2021 Sep 9. PMID: 34375508; PMCID: PMC8487054. |
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[2]. Wu Y, Yu Q, et,al.Hemin chloride-primed dendritic cells suppress allergic airway inflammation through releasing extracellular vesicles. J Leukoc Biol. 2022 Apr;111(4):837-848. doi: 10.1002/JLB.3A0321-175R. Epub 2021 Jul 23. PMID: 34296788; PMCID: PMC9292814. |
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[3]. Banesh S, Layek S, et,al. Hemin chloride acts as CD36 ligand to activate down-stream signalling to disturb immune responses and cytokine secretion from macrophages. Immunol Lett. 2022 Mar;243:1-18. doi: 10.1016/j.imlet.2022.01.004. Epub 2022 Jan 31. PMID: 35104496. |
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[4]. Chen HH, Lu PJ, et,al. Heme oxygenase-1 ameliorates kidney ischemia-reperfusion injury in mice through extracellular signal-regulated kinase 1/2-enhanced tubular epithelium proliferation. Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2195-201. doi: 10.1016/j.bbadis.2015.07.018. Epub 2015 Jul 30. PMID: 26232688. |
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[5]. Vanova K, Boukalova S, et,al. Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells. BMC Cancer. 2016 May 12;16:309. doi: 10.1186/s12885-016-2343-9. PMID: 27175805; PMCID: PMC4866069. |
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[6]. Almahi WA, Yu KN, et,al. Hemin chloride enhances radiosensitivity of lung cancer cells through ferroptosis. Exp Cell Res. 2022 Jan 1;410(1):112946. doi: 10.1016/j.yexcr.2021.112946. Epub 2021 Nov 24. PMID: 34826424. |
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[7]. Jones NM, Sysol JR,et,al. Cortactin loss protects against Hemin chloride-induced acute lung injury in sickle cell disease. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 1;322(6):L890-L897. doi: 10.1152/ajplung.00274.2021. Epub 2022 May 3. PMID: 35503995; PMCID: PMC9169831. |
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We Devoted Ourselves To The Development Of Biomedical Research Reagent. |
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