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Recombinant Human HER2/ErbB2 |
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Cat.No.: |
CYT-P04626 |
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Product Background |
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Recombinant Human HER2 |
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Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR, ERBB3 and ERBB4. HER2 associates with the 5''''''''-TCAAATTC-3'''''''' sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
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Product Information |
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Source |
Human Cells |
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Molecular Weight |
70.2 KDa |
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AA Sequence |
Recombinant Human Receptor Tyrosine-protein Kinase ErbB-2 is produced by our Mammalian expression system and the target gene encoding Thr23-Thr652 is expressed with a 6His tag at the C-terminus. |
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Biological Activity |
Loaded Anti-Human HER2 mAb-Fc on Protein A Biosensor, can bind Human HER2-His with an affinity constant of 1.36 nM as determined in BLI assay. |
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Physical Appearance |
Lyophilized from a 0.2 ¦Ìm filtered solution of PBS,pH7.4 |
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Formulation |
Lyophilized from a 0.2 ¦Ìm filtered solution of PBS,pH7.4 |
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Endotoxin |
< 1 EU/µg as determined by LAL test |
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Reconstitution |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. |
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Purity |
Greater than 90% as determined by reducing SDS-PAGE |
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Stability & Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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12 months from date of receipt, -20 to -70 ¡ãC as supplied. |
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1 month, 2 to 8 ¡ãC under sterile conditions after reconstitution. |
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3 months, -20 to -70 ¡ãC under sterile conditions after reconstitution. |
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Usage Information |
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This product is offered by BioCytoSci only for Scientific Research & Laboratory USE. NOT FOR OTHER USE. |
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Order Information |
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Cata.No. |
Quantity |
Price($) |
Price($) |
Price(£¤) |
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CYT-P04626 |
10ug |
$120.00 |
€132.00 |
£¤1,200.00 |
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CYT-P04626 |
50ug |
$260.00 |
€286.00 |
£¤2,600.00 |
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CYT-P04626 |
1mg |
$3,560.00 |
€3,916.00 |
£¤35,600.00 |
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Free Delivery on orders over $200.00. |
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We Devoted Ourselves To The Development Of Biomedical Research Reagent. |
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