NF-¦Ê¦¢ activator 1,2387524-59-4

Cat.No.:IC-1080841

Product Information

Biological Activity

NF-¦Ê¦¢ activater 1 (compound 32) is a potent NF-¦Ê¦¢ activator with EC50 of 0.9 ¦ÌM. NF-¦Ê¦¢ activater 1 induces superoxide dismutase (SOD)2 mRNA expression.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical structure

Chemical Information

M.Weight

314.33

Formula

C16H11FN2O2S

CAS No.

2387524-59-4

Purity

 >98.00%

Solubility

100 mg/mL in DMSO

Storage

Keep in dark place,Inert atmosphere,2-8¡ãC

Reference

1. Mathew B, et al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS [published online ahead of print, 2020 Oct 22]. Eur J Med Chem. 2020;112952.  [Content Brief]

Order Information

Cat./REF.

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

IC-1080841

1mg

$119.40

€ 143.28

£¤1,194.00

£¤23,760.60

IC-1080841

5mg

$298.30

€ 357.96

£¤2,983.00

£¤59,361.70

IC-1080841

10mg

$481.90

€ 578.28

£¤4,819.00

£¤95,898.10

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