Cat.No.:IC-0321566

Product Information

Biological Activity

TREM2 agonist-2 (I-192) is an orally active and potent myeloid triggered receptor 2 (TREM2) agonist for the study of neurodegenerative diseases.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical structure

Chemical Information

M.Weight

451.92

Formula

C24H23ClFN5O

CAS No.

2738485-98-6

Purity

 >98.00%

Solubility

45.19 mg/mL (100 mM£© in DMSO

Storage

Powder: -20¡ãC for 3 years

Reference

1.InventorLara C. CZABANIUKT£¬et al.Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use:WO2021226629A1.

Order Information

Cat./REF.

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

IC-0321566

5mg

$689.00

€ 826.80

£¤6,890.00

£¤137,111.00

IC-0321566

25mg

$1,450.00

€ 1,740.00

£¤14,500.00

£¤288,550.00

IC-0321566

50mg

$1,809.00

€ 2,170.80

£¤18,090.00

£¤359,991.00

We Devoted Ourselves To The Development Of Biomedical Research Reagent.