LL-37, human ,154947-66-7

Cat.No.:IC-0906523

Product Information

Biological Activity

LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing[1][2][3].

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical structure

Chemical Information

Leu-Leu-Gly-Asp-Phe-Phe-

Arg-Lys-Ser-Lys-Glu-

Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-

Val-Gln-Arg-Ile-Lys-Asp-

Phe-Leu-Arg-Asn

-Leu-Val-Pro-Arg-Thr-Glu-Ser

M.Weight

4493.26

Formula

C205H340N60O53

CAS No.

154947-66-7

Purity

>98.00%

Solubility

50 mg/ml  in Water.(11.13 mM)

Storage

-20¡æ, protect from light

Reference

[1]. D¨¹rr UH, et al. LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim Biophys Acta. 2006 Sep;1758(9):1408-25.
[2]. Huang LC, et al. Multifunctional roles of human cathelicidin (LL-37) at the ocular surface. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2369-80.
[3]. Hou M, et al. Antimicrobial peptide LL-37 and IDR-1 ameliorate MRSA pneumonia in vivo. Cell Physiol Biochem. 2013;32(3):614-23.

Order Information

Cat./REF.

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

IC-0906523

5mg

$135.50

€ 162.60

£¤1,355.00

£¤26,964.50

IC-0906523

10mg

$223.60

€ 268.32

£¤2,236.00

£¤44,496.40

IC-0906523

1mg

$85.00

€ 102.00

£¤850.00

£¤16,915.00

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