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Exendin-4£¬IC-0324402
Click£º757     Release date£º2020-6-25    Author£ºAdministrator    Source£ºOriginal

Exendin-4£¬IC-0324402

Glucagon-like peptide-1 (GLP-1) is an enteroendocrine hormone that has a capacity, when administered exogenously, to normalize blood glucose levels in type 2 diabetes mellitus. Exendin-4, a 39-amino acid (AA) peptide, is a long-acting agonist at the GLP-1 receptor with an IC50 value of 3.22 nM[3]. In human umbilical vein endothelial cells (HUVECs), exendin-4 significantly increased NO production, endothelial NO synthase (eNOS) phosphorylation, and GTP cyclohydrolase 1 (GTPCH1) level in a dose-dependent manner[4]In vivoob/ob mice sustained a reduction in the net weight gained during exendin-4 treatment (10 ¦Ìg/kg or 20 ¦Ìg/kg for 60 days). Furthermore, serum glucose and hepatic steatosis was significantly reduced and insulin sensitivity was improved in exendin-4 treated ob/ob mice[5].

[1]Tsutsumi Y, Nomiyama T, et al. Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth. PLoS One. 2015 Oct 6;10(10):e0139709.

[2]Zhou Y, He X, et al. Exendin-4 attenuates cardiac hypertrophy via AMPK/mTOR signaling pathway activation. Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):394-9.

[3]Doyle ME, Theodorakis MJ, et al. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regul Pept. 2003 Jul 15;114(2-3):153-8

[4]Wei R, Ma S, Wang C, et al. Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner. Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E947-57

[5]Ding X, Saxena NK, Lin S, Gupta NA, Anania FA. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology. 2006 Jan;43(1):173-81

Order Information

Cat./REF.

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

IC-0324402

5mg

$65.00

€ 78.00

£¤650.00

£¤12,935.00

IC-0324402

25mg

$267.00

€ 320.40

£¤2,670.00

£¤53,133.00

IC-0324402

100mg

$950.00

€ 1,140.00

£¤9,500.00

£¤189,050.00

 

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