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Gastrin I£¬Human£¬IC-0321080
Click£º370     Release date£º2020-6-25    Author£ºAdministrator    Source£ºOriginal

Gastrin I£¬Human£¬IC-0321080

The peptide cholecystokinin (CCK), originally discovered in the gastrointestinal tract, has been shown to mediate pancreatic secretion and contraction of gallbladder. Two types of CCK receptors (CCK1 found in the gut and CCK2 found in the brain) have thus been distinguished. Gastrin-1, human, a endogenous peptide produced in the stomach, increases gastric acid secretion via acting at CCK2 receptor[1]. In anaesthetized rats, gastrin-1, human (1.5, 5, 15 and 45 nmol/kg, i.v.) increased both pepsinogen and acid secretion. After pretreatment with omeprazole, gastrin-1, human failed to stimulate acid secretion, while it increased pepsinogen output. In rats with gastric perfusion of acid solutions, gastrin-1, human increased peptic output in a pH-independent manner either with or without pretreatment with omeprazole[2].

¡¾1¡¿Noble F, et al. International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol Rev. 1999 Dec;51(4):745-81

¡¾2¡¿Blandizzi C, et al. CCK1 and CCK2 receptors regulate gastric pepsinogen secretion. Eur J Pharmacol. 1999 May 28;373(1):71-84

Order Information

Cat./REF.

Size

Price($£©

Price(€)

Price(£¤/CNY£©

Price(£¤/JYP£©

IC-0321080

1mg

$2,100.00

€ 2,520.00

£¤21,000.00

£¤417,900.00

IC-0321080

5mg

$980.00

€ 1,176.00

£¤9,800.00

£¤195,020.00

IC-0321080

10mg

$1,500.00

€ 1,800.00

£¤15,000.00

£¤298,500.00

 



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