Reagent
Recombinant Mouse NGF beta,CYT-P01139
Click£º2325 Release date£º2020-6-16 Author£ºAdministrator Source£ºOriginal
Recombinant Mouse NGF beta,CYT-P01139
Function
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:20036257).
Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:22649032).
The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse (PubMed:22155786).
In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (PubMed:20036257).
Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity).
Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer (PubMed:22649032, PubMed:26144237).
The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (PubMed:22649032).By Similarity
4 Publications
Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:22649032).
The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse (PubMed:22155786).
In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (PubMed:20036257).
Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity).
Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer (PubMed:22649032, PubMed:26144237).
The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (PubMed:22649032).By Similarity
Features
Showing features for binding site.
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Order Information |
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Cat./REF. |
Size |
Price($£© |
Price(€) |
Price(£¤/CNY£© |
Price(£¤/JYP£© |
|
CYT-P07141 |
2ug |
$98.00 |
€ 117.60 |
£¤980.00 |
£¤19,502.00 |
|
CYT-P07141 |
10ug |
$245.00 |
€ 294.00 |
£¤2,450.00 |
£¤48,755.00 |
|
CYT-P07141 |
100ug |
$980.00 |
€ 1,176.00 |
£¤9,800.00 |
£¤195,020.00 |
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