Reagent
¦Á-Synuclein human (S7820)
Click£º2704 Release date£º2014-12-18 Author£ºAdministrator Source£ºOriginal
¦Á-Synuclein human (S7820)
| Price | Recombinant Source | Purity Assay | Size |
| $890.00 | Expressed in E. coli | ¡Ý90% (SDS-PAGE) | 500ug |
| Store At | Form | Type of shipping | Shelf |
| −20¡ãC | lyophilized powder | dry ice | 12months |
Application
Human ¦Á-synuclein has been used to study the immunodetection of ¦Á-syn monomers and its aggregates.It has also been used in microscale thermophoresis to study protein-protein interactions
Biochem/physiol Actions
140-amino acid protein (apparent molecular weight 19-20 kDa) encoded by a simple gene consisting of six exons on human chromosome 4. Induces polymerization of tubulin into microtubules and functions in the modulation of dopamine transporter function, regulating the synaptic tone of dopamine. Disruption of this function can ultimately lead to neurodegeneration of nerve terminals. Highly abundant in presynaptic terminals, a major component of Lewy bodies, the neuronal cytoplasmic inclusions that are a hallmark of diverse neurodegenerative disorders such as Parkinson¡¯s disease (PD), dementia with Lewy bodies (filamentous inclusions), Lewy body variant of Alzheimer¡¯s disease, and multiple system atrophy. Pathogenic point mutations in the ¦Á-synuclein gene are linked to familial Parkinson¡¯s disease.
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