YO-01027 (Dibenzazepine),209984-56-5 |
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Cat.No.: |
IC-015654 |
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Product Information |
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Biological Activity |
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YO-01027 (also called dibenzazepine; DBZ; YO01027) is a novel, potent, orally bioavailable, dipeptidic inhibitor of the ¦Ã-secretase with potential antineoplastic activity. It inhibits ¦Ã-secretase with IC50s of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively. It shows high in vivo antitumor efficacy in C57BL/6 mice bearing MCF-7 tumors. |
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Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines) |
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Species |
Mouse |
Rat |
Rabbit |
Guinea pig |
Hamster |
Dog |
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Weight (kg) |
0.02 |
0.15 |
1.8 |
0.4 |
0.08 |
10 |
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Body Surface Area (m2) |
0.007 |
0.025 |
0.15 |
0.05 |
0.02 |
0.5 |
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Km factor |
3 |
6 |
12 |
8 |
5 |
20 |
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Animal A (mg/kg) = Animal B (mg/kg) multiplied by (Animal B Km / Animal A Km) |
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Order Information |
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Quantity |
Price($) |
Price(€) |
Availability |
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10mg |
$160.00 |
€192.00 |
In stock |
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25mg |
$260.00 |
€312.00 |
In stock |
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50mg |
$420.00 |
€504.00 |
In stock |
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Free Delivery on orders over $350.00. |
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Chemical Information |
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Molecular Weight |
463.48 |
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Formula |
C26H23F2N3O3 |
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CAS Number |
209984-56-5 |
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Purity |
>98.00% |
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Solubility |
DMSO : 50 mg/mL (107.88 mM) |
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Storage |
-20¡æ |
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Reference |
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[1]. Groth C, et al. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Mol Pharmacol. 2010 Apr;77(4):567-74. |
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[2]. Fuwa H, et al. Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. ACS Chem Biol. 2007 Jun 15;2(6):408-18. |
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We Devoted Ourselves To The Development Of Biomedical Research Reagent. |
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