Product Information

Biological Activity

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B. Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species

Mouse

Rat

Rabbit

Guinea pig

Hamster

Dog

Weight (kg)

0.02

0.15

1.8

0.4

0.08

10

Body Surface Area (m2)

0.007

0.025

0.15

0.05

0.02

0.5

Km factor

3

6

12

8

5

20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by  (Animal B Km / Animal A Km)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Order Information

Quantity

Price($)

Price($)

Availability

5g

$80.00

€88.00

In stock

25g

$120.00

€132.00

In stock

100g

$350.00

€385.00

In stock

Free Delivery on orders over $350.00.

Chemical Information

Molecular Weight

267.3

Formula

C₁₄H₂₁NO₄

CAS Number

632-93-9

Purity

>98%

Solubility

DMF: 30 mg/ml,DMF:PBS (pH 7.2); (1:7): 0.125 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml

Storage

 at -20°C

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