Erastin,571203-78-6 |
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Cat.No.: |
IC-0127741 |
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Product Information |
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Biological Activity |
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Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3)[1].Erastin triggers oxidative, iron-dependent cell death. Treatment of NRAS-mutant HT-1080 fibrosarcoma cells with the RSL molecule erastin (10 µM) results in a time-dependent increase in cytosolic and lipid ROS beginning at 2 hours[1]. Cell death triggered by erastin is significantly inhibited by antioxidants (e.g., ¦Á-tocopherol, butylated hydroxytoluene, and ¦Â-carotene) and iron chelators, suggesting that ROS- and iron-dependent signaling is required for erastin-induced ferroptosis. Erastin can directly bind to VDAC2/3 in BJeLR cells. Knockdown of VDAC2 and VDAC3, but not VDAC1, leads to erastin resistance. Erastin has the ability to reduce glutathione level by directly inhibiting cystine/glutamate antiporter system Xc− activity, with activation of the ER stress response[2]. Erastin potently inhibits HT-29 cell survival. Erastin shows a dose-dependent effect, and 30 ¦ÌM of erastin displays the most dramatic effect[3].Intraperitoneal injection of erastin at well-tolerated doses dramatically inhibits HT-29 xenograft growth in severe combined immunodeficient mice[3]. |
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Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines) |
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Species |
Mouse |
Rat |
Rabbit |
Guinea pig |
Hamster |
Dog |
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Weight (kg) |
0.02 |
0.15 |
1.8 |
0.4 |
0.08 |
10 |
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Body Surface Area (m2) |
0.007 |
0.025 |
0.15 |
0.05 |
0.02 |
0.5 |
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Km factor |
3 |
6 |
12 |
8 |
5 |
20 |
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Animal A (mg/kg) = Animal B (mg/kg) multiplied by (Animal B Km / Animal A Km) |
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Order Information |
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Quantity |
Price($£© |
Price(€) |
Price(£¤/CNY£© |
Price(£¤/JYP£© |
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1mg |
$60.00 |
€72.00 |
£¤600.00 |
¥11,940.00 |
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5mg |
$120.00 |
€144.00 |
£¤1,200.00 |
¥23,880.00 |
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50mg |
$450.00 |
€540.00 |
£¤4,500.00 |
¥89,550.00 |
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Free Delivery on orders over $350.00. |
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Chemical Information |
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Molecular Weight |
547.04 |
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Formula |
C30H31ClN4O4 |
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CAS Number |
571203-78-6 |
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Purity |
>98% |
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Solubility |
DMSO : 12.5 mg/mL (22.85 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) |
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Storage |
at -20¡ãC |
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Reference |
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[1]. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012 May 25;149(5):1060-72. |
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We Devoted Ourselves To The Development Of Biomedical Research Reagent. |